Inhalation of airborne toluene is the main source of human ex- EC number: 202-851-5 | CAS number: 100-42-5 . IARC: 2B - Group 2B: Possibly carcinogenic to humans (Styrene) Reproductive toxicity Suspected of damaging the unborn child. Chronic toxicity and reproductive performance were evaluated in groups of rats receiving styrene monomer in their drinking water at nominal concentrations of 0, 125, or 250 ppm. 32 Issue. (Birth Defects Research Part B: Developmental and Reproductive Toxicity, 2005). 3.2.1.1 Death There have been no reports of deaths in humans directly associated with exposure to styrene in the workplace (EPA 1985a; Gosselin et al. ACGIH (2010) Background on listing by the Labor Code mechanism: Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list. 228-247 Language. styrene reproductive toxicity. The characteristic unpleasant smell and low odour threshold (0.1 ppm; 0.43 mg/m3) allows styrene to be readily detected in the workplace at levels below the occupational exposure standards. Experiments were performed to evalute reproductive and developmental toxicology in rats and rabbits exposed to styrene oxide by inhalation. acute toxicity, hearing damage and is suspected of reproductive toxicity. In light of all the available information, it is concluded that migration of styrene … Maternal toxicity, increased preimplantation loss of fetuses, reduced fetal weight, and Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility. Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. Article. Detailed results of these studies are available from the National Institute for Occupational Safety 1. CATEGORY 2: Suspected human reproductive toxicant Substances are classified in Category 2 for reproductive toxicity when there is some evidence from humans or experimental animals, possibly supplemented with other information, of an adverse effect on sexual function and fertility, or on development, and where the evidence is not sufficiently convincing to place the substance in Category 1. Gary P. Carlson, Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice, Toxicology, 10.1016/j.tox.2012.02.006, 294, 2-3, (104-108), (2012). Nonneoplastic lesions were observed in the brain, thymus, spleen, liver, kidney, and reproductive organs of males and females and were considered due to overt toxicity. styrene oxide, a finding suggesting preimplantation loss. The reproductive and developmental toxicity of styrene has been studied in animals and humans. 2000 Is Peer Reviewed? Female reproductive toxicity. Possible Reproductive Toxicity of Styrene in Peripubertal Male Mice. He has published over 25 such articles in peer-reviewed journals, including the review article “Styrene Metabolism and Toxicokinetics in the SIRC Review” (1994), and, more recently, “Two Generation Reproduction Study of Styrene by Inhalation in Crl-CD Rats”. The listing of α-methyl styrene for the endpoint of female reproductive toxicity is effective July 29, 2011. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure 98-83-9. Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive … Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats Styrene will polymerise when contaminated by oxidising agents and most halides. Suspected human reproductive toxicant Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure Causes damage to organs through prolonged or repeated exposure. Assessments included gonadal function, estrous cyclicity, mating behavior, conception rate, gestation, parturition, lactation, and weaning in the F 0 and F 1 generations, and F 1 generation offspring growth and development. Yes Journal. A review of the developmental and reproductive toxicity of styrene Author(s) Brown, NA; Lamb, JC; Brown, SM; Neal, BH Year. That is why we gather list of chemicals known to cause cancer or reproductive toxicity below: 1. 1984; NIOSH 1983). This study was conducted to evaluate the potential adverse effects of styrene on reproductive capability from whole‐body inhalation exposure of F 0 and F 1 parental animals. Acute toxicity, Inhalation (Category4), H332 Skin irritation (Category2), H315 Eye irritation (Category 2), H319 Reproductive toxicity (Category 2), H361d Specific target organ toxicity - repeated exposure (Category 1), H372 For the full text of the H-Statementsmentioned in this … Toluene is also used as a solvent for paints, lacquers, and adhesives. ... We don’t know what causes most fertility problems, miscarriages, birth defects, and other reproductive problems. Toxicity Data 1) Information on adverse effects on human health There is no report on the effects on human health due to exposure to styrene dimer and trimer. Styrene 100- 42 -5 90 - 100% Yes 3. systemic toxicity is characterised by progressive loss of consciousness leading to coma inhalation of styrene causes irritation of mucous membranes, coughing and wheezing styrene inhalation may also lead to "styrene sickness", which includes ... Repr. There are good reasons that the reduction in grip strength is not an indication for a specific developmental effect but is rather attributable to a combination of reduced body weight and chance variations in data. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. Acute toxicity * Oral * Dermal * Inhalation Skin corrosion/irritation Serious eye damage/irritation Respiratory sensitization Skin sensitization Carcinogenicity * IARC * OSHA * ACGIH * NTP * EU CLP Germ cell mutagenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard The reproductive and developmental toxicity of styrene has been studied in animals and humans. Reproductive performance (i.e. The animal studies on styrene have diverse study designs and conclusions. An LC 2) Information on endocrine system and reproductive system (1) in vitro test results related to receptor binding (Attachment-3) Reproductive Toxicity Risk Assessment Published on October 31, 1996, Federal Register 61(212):56274-56322 These guidelines replace two proposed guidelines: Proposed Guidelines for Female Reproductive Risk and Proposed Guidelines for Male Reproductive Risk, both dated June 30, 1988. No information is available on the reproductive or developmental effects of styrene oxide in humans. Regulatory Toxicology and Pharmacology ISSN: 0273-2300 EISSN: 1096-0295 Volume. • Category 1B for reproductive toxicity “a presumed human reproductive toxicant” – The SPA undertook a careful assessment of the available scientific data and concluded that the weight of available evidence demonstrates that Styrene is not selectively toxic to development and hence classification for reproductive toxicity is not warranted. Reproductive Toxicity… These chemicals include styrene, methyl methacrylate, epoxy resins, vinyl chloride, and others. mating behaviour and fertility), gestation length, litter data (number of pups, sex ratio), postnatal survival, sperm evaluations and primordial follicle counts were not adversely affected by styrene exposure across the generations. Hazards Identification Emergency Overview ----- DANGER! Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system. Styrene-butadiene copolymer 9003-55-8 New Jersey Right to Know Components Styrene-butadiene copolymer 9003-55-8 California Prop. In animals, inhalation studies indicate that the acute toxicity of styrene is low to moderate. 3 Page Numbers. α-Methyl styrene. July 2000; Endocrine Journal 47(3):343-7 47(3):343-7 Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. known effects of inhalation exposure of humans and animals to styrene. Reproductive and Developmental Toxicity of Toluene: A Review by James M. Donald,* Kim Hooper,* and Claudia ... styrene production and coke-oven operations (4,8). Styrene NAC: 02/2008 vii repeated exposure of rats through gestation day 6 – 20 to 300 ppm, an increased neonatal death rate and delayed postnatal development was observed compared to … In rabbits exposed to styrene ... ated the reproductive toxicity of ethylene oxide, propylene oxide, butylene oxide, and styrene oxide. Maternal toxicity and increased fetal mortality have been observed in rats and rabbits exposed to styrene oxide by inhalation. One reproductive toxicity study in female workers from the plastic manufacturing industry exposed to 13 or 52 ppm styrene has been negative for menstrual disorders (Lemasters et al., 1985), whereas another study in humans has shown increased frequency of spontaneous abortions and a decreased frequency of births (Lemasters et al., 1989). ... Styrene Group I Chemical High Exposure Concern Not applicable Other Adverse Effects The toxicological properties have not been fully investigated. FLAMMABLE LIQUID AND VAPOR. Extensive mortality occurred in rats that received prolonged exposure to 100 ppm styrene oxide while 300 ppm was rapidly lethal. The acute toxicity of styrene appears to be unrelated to its biotransformation. Styrene oxide, like many intermediate metabolites of foodstuffs, is genotoxic and, if introduced directly into the stomachs of rodents in high doses/concentrations, gives rise to cancers of the forestomach. The shocking fact about styrene which is the main substance that form our daily styrofoam product made us realize how big is the exposure we already had in our body. The animal studies on styrene have diverse study designs and conclusions. Styrene: Can it be used ... or other reproductive harm” by maintaining and updating a list of chemicals “known in the state of California to cause cancer or reproductive toxicity” and also to provide warnings to consumers who may come into contact with products that contain the listed chemicals. 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